Structural revision of 19, 20-epoxycytochalasin D and its cytotoxic activity

Abstract

The structure of 19(αH), 20(αH)-epoxycytochalasin D from the fungus Xylaria hypoxylon reported by Espada et al.,1 has been revised to 19(αH), 20(αH)-epoxycytochalasin D (1) by spectroscopic methods PH NMR, 13C NMR, HMQC, HMBC, and NOESY), and single-crystal X-ray diffraction analysis. Cytotoxic activity against tumor cell line was assessed for compounds 1, and found to show potent cytotoxic activity against tumor cell line P-388.