3-(Thiophen-2-yl)-4,5-dihydro-1H-pyrazole-1-carboximidamides were efficiently prepared through a cyclocondensation of thiophenylchalcones with aminoguanidine hydrochloride under ultrasonic conditions in the presence of KOH and ethanol as a green solvent in short reaction times (15-35 min) and good yields (62-95%). All compounds produced were evaluated against the human Jurkat and RS4;11 acute lymphoblastic leukemia cell lines of T- and B-cell origin, respectively, and the K562 myelogenous leukemia cell line. Six compounds presented half maximal inhibitory concentration (IC50) values around 15 μmol L-1 and five compounds presented IC50 values around 40 μmol L-1 for at least one of the three cell lines analyzed. One compound was not significantly cytotoxic, presenting IC50 value > 100 μmol L-1.
CITATION STYLE
Dos Santos, E. F. S., Cury, N. M., Do Nascimento, T. A., Raminelli, C., Casagrande, G. A., Pereira, C. M. P., … Pizzuti, L. (2017). Ultrasound-promoted synthesis of 3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole-1-carboximidamides and anticancer activity evaluation in leukemia cell lines. Journal of the Brazilian Chemical Society, 28(2), 217–224. https://doi.org/10.5935/0103-5053.20160166
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