Phosphotriesterase-related protein sensed albuminuria and conferred renal tubular cell activation in membranous nephropathy

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Abstract

Background: Membranous nephropathy (MN) is a common cause of nephrotic syndrome that may progress to end-stage renal disease (ESRD). The formation of MN involves the in situ formation of subepithelial immune deposits and leads to albuminuria; however, the underlying mechanism of how MN leads to ESRD remains unclear. The aim of this study was to investigate the expression and biological functions of phosphotriesterase-related protein (PTER) in MN. Results: In the progression of MN, the expression of PTER increased significantly and was mainly expressed in the renal tubular cells. Both mRNA and protein expression levels of PTER were increased in a concentration- and time-dependent manner in the in vitro albuminuria tubular cell model. Silencing the expression of PTER by RNA interference diminished albuminuria-induced inflammatory and pro-fibrotic cytokines production. Conclusions: Our findings reveal that PTER may sense albuminuria in the progression of MN, induce tubular cell activation and lead to ESRD. © 2014 Cheng et al.; licensee BioMed Central Ltd.

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Cheng, C. W., Chang, L. C., Tseng, T. L., Wu, C. C., Lin, Y. F., & Chen, J. S. (2014). Phosphotriesterase-related protein sensed albuminuria and conferred renal tubular cell activation in membranous nephropathy. Journal of Biomedical Science, 21(1). https://doi.org/10.1186/1423-0127-21-32

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