Sequential events during the quiescence to proliferation transition establish patterns of follicle cell differentiation in the Drosophila ovary

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Abstract

Stem cells cycle between periods of quiescence and proliferation to promote tissue health. In Drosophila ovaries, quiescence to proliferation transitions of follicle stem cells (FSCs) are exquisitely feeding-dependent. Here, we demonstrate feeding-dependent induction of follicle cell differentiation markers, eyes absent (Eya) and castor (Cas) in FSCs, a patterning process that does not depend on proliferation induction. Instead, FSCs extend micron-scale cytoplasmic projections that dictate Eya-Cas patterning. We identify still life and sickie as necessary and sufficient for FSC projection growth and Eya-Cas induction. Our results suggest that sequential, interdependent events establish long-term differentiation patterns in follicle cell precursors, independently of FSC proliferation induction.

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Lee, E. H., Zinshteyn, D., Miglo, F., Wang, M. Q., Reinach, J., Chau, C. M., … O’Reilly, A. M. (2023). Sequential events during the quiescence to proliferation transition establish patterns of follicle cell differentiation in the Drosophila ovary. Biology Open, 12(1). https://doi.org/10.1242/bio.059625

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