Influence of acidosis on cardiotonic effects of milrinone

Abstract

Background: The present study was designed to determine whether augmentation of cardiac performance by milrinone is affected by acidosis in in vivo canine and in vitro guinea pig preparations, and to elucidate a mechanism in relation to the cyclic adenosine monophosphate (cAMP) formation. Methods: ventilated dogs were randomly assigned to a control group (arterial pH [pHa] ≃ 7.4, base excess [BE] >-2 mM; n = 7), mild acidosis group (pHa ≃ 7.2, BE < 7, BE