Clobazam is a benzodiazepine derivative used as an antiepileptic agent for the treatment of focal and generalized seizures and drug-resistant epilepsy associated with Lennox-Gastaut Syndrome. While somnolence and mood-related side effects are commonly observed, acute macroglossia following initiation of Clobazam therapy has not been previously reported in the medical literature. In this case report, we present a female pediatric patient who developed significant tongue swelling with protrusion beyond the oral cavity after initiation of Clobazam for treatment-resistant epilepsy. Symptoms were unresponsive to antihistamines and steroids but resolved gradually in the days following discontinuation of Clobazam with no lingering sequelae.
CITATION STYLE
Zhang, J. F., Nickerson, K., Piryani, R., Farooq, O., & Swayampakula, A. K. (2022). Macroglossia Associated With Clobazam Administration: A Case Report and Literature Review. Frontiers in Neurology, 13. https://doi.org/10.3389/fneur.2022.900763
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