Tin-Promoted One-Pot Synthesis of Aryl/Trifluoromethyl Group Substituted Homoallylic N-Acylhydrazines

Abstract

A series of trifluoromethylated homoallylic N-acylhydrazines were obtained from one-pot reaction of aryl trifluoroketones, acylhydrazines and allyl bromide promoted by tin powder in the presence of boron trifluoride diethyl etherate (BF3·OEt2). The features of this process include good yields, wide substrate scope, mild conditions and easy operation. Trifluoromethylated homoallylic N-acylhydrazines are useful trifluoromethyl building blocks. They can be easily transformed into trifluoromethylated nitrogen-containing compounds.