Pathobiology of vascular disease

Abstract

Knowledge of the structure and function of the circulatory system and the consequences of temporary or permanent disruption of regional blood flow is imperative in surgery because operative procedures by their very nature disrupt tissues and their blood supply. Moreover, reconstruction of blood vessels is often necessary as they fail from disease or trauma. Repair or replacement requires an understanding of vascular anatomy, vessel wall structure, hemodynamics, and the healing properties of vessels and grafts. This chapter focuses on the arterial system, providing an overview of its origin, structure, and function. The pathobiology of common artery wall diseases is then considered. Subsequent chapters focus on contemporary evidence-based management of regional artery wall pathology. © 2008 Springer New York.