HPV status and its genomic integration affect survival of patients with cervical cancer

Abstract

The aim of this study is the evaluation of relapse-free and overall survival of HPV-positive patients with regard to the physical status of type 16 HPV and of HPV-negative patients with primary cervical cancer. As a main result of the study, the predictive value of the physical status of type 16 HPV was determined for relapse-free and overall survival of patients with cervical cancer. Episomal form of the virus is a favorable predictive factor. Integrated form of the virus is a severely unfavorable predictive factor and survival of such patients is significantly lower than of HPV-patients and patients with mixed form of the virus. The results of the research are data on survival of patients with cervical cancer depending on the physical status of the virus (for HPV+ patients) and of patients with HPV-negative cancer.