Autoagglutination (AA) is a virulence-associated trait typical of various pathogenic bacteria, including Yersinia pestis. In this study, we show that AA in Y. pestis is a complex phenomenon determined by the HCP-like protein of T6SS which is encoded by ypo0502 and by the siderophore Yersiniachelin (Ych) which is encoded by the ysu locus. Down-regulation of YPO0502 expression by antisense RNA abrogates AA in G8786 (Hms +) and EV76 (Hms -) Y. pestis strains. The deletion of Ych biosynthetic genes ypo1530-1532 in EV76 though does not abolish AA results in its noticeable depression. © 2012 Springer Science+Business Media New York.
CITATION STYLE
Podladchikova, O., Rykova, V., Antonenka, U., & Rakin, A. (2012). Yersinia pestis autoagglutination is mediated by HCP-Like protein and siderophore yersiniachelin (Ych). In Advances in Experimental Medicine and Biology (Vol. 954, pp. 289–292). Springer New York LLC. https://doi.org/10.1007/978-1-4614-3561-7_36
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