Pancreatic histological studies in mice induced by alloxan and steeping okra coffee (Abelmoschus esculentus [L.] Moench)

Abstract

Introduction: Those suffering from diabetes mellitus (DM) form one of the high-risk groups for developing severe illness from COVID-19. Steeping okra coffee (Abelmoschus esculentus [L.] Moench) is empirically used in DM treatment. Objective: To determine the pancreatic histology in mice induced by alloxan and steeping okra coffee (SOC). Method: This was an experimental research using 16 mice that were divided into four groups, 1) control group (alloxan and aquades) and SOC Group; 2-4), treated with steeping okra coffee at 1820, 3640, and 5460 mg/KgBW concentration for ten days. Results: The treatment groups 2 and 3 showed an improvement in the damage of acinar cells and islets of Langerhans by 100%. On the other hand, there was still 25% vacuolisation on the islets of Langerhans in the group 4 treatment group. Conclusion: The steeping okra coffee repaired the islets of Langerhans cells and acinar cells that were vacuolised.