EVALUATION OF SERUM LEVEL OF 25-HYDROXY VITAMIN D IN VITILIGO PATIENTS

Abstract

Introduction: Vitiligo is an acquired skin disease characterized by loss of functional melanocytes from the epidermis. Despite the several factors studied, the pathogenesis of vitiligo remains unclear. Vitiligo could be associated with low vitamin D levels. Objective: The aim of this study was to evaluate serum 25(OH) D levels in vitiligo patients in comparison of normal controls. Patients and Methods: After meeting inclusion and exclusion criteria, serum 25 hydroxy vitamin D levels were assayed in all subjects included in this case control study (40 patients and 40 age and sex matched healthy individuals). Vitiligo Area & Severity index (VASI), BSA, age of patients and duration of vitiligo were evaluated in relation to vitamin D level. Results: A total of 80 participants were enrolled in our study, 40 patients with non-segmental vitiligo and 40 who served as controls. The mean serum level of vitamin D were significantly decreased in the patients group as compared with the control group ( 20.75 nmol/l ± 9.16 vs 39.90 nmol/l ±12.69, P < 0.05). There was non-significant correlation between vitamin D level, age, duration of vitiligo and body surface area (P>0.05). However there was a significant correlation between vitamin D level and Vitiligo Area & Severity Index (VASI) score. Conclusion: In this study, we found a significant 25(OH) D deficiency in patients with non-segmental vitiligo, suggesting that vitamin D deficiency may play a role in the pathogenesis of vitiligo.