LEUCOGRAMA E METABOLISMO OXIDATIVO DOS NEUTRÓFILOS DE CÃES COM LEISHMANIOSE VISCERAL ANTES E APÓS O TRATAMENTO COM ANTIMONIATO DE MEGLUMINA E ALOPURINOL

Abstract

Leukogram and neutrophil oxidative metabolism from dogs with visceral leishmaniasis (VL) were compared before and after treatment with meglumine antimoniate (AM) and with an association of meglumine antimoniate and allopurinol (AMA). The results obtained demonstrated that neutrophils of dogs with VL do not lose their capacity of reducing NBT and that oxidative metabolism has been more active in the majority of the cases. After treatment with AM and AMA, dogs with VL presented a redution of neutrophils oxidative metabolism, suggesting that this decrease was related with the decrease in the number of parasites and a probable inhibitor effect of these drugs on neutrophils oxidative metabolism.  KEYWORDS: Glucantime, Leishmania sp, nitroblue tetrazolium (NBT), neutrophil functions.