Basic aspects of cardiac remodelling

Abstract

It has been defined by Conn and colleagues in 2000 that "Cardiac remodelling may be characterized as genome expression, molecular, cellular and interstitial changes that are manifested clinically as changes in size, shape and function of the heart after cardiac injury", associated with ventricular dysfunction, malignant arrhythmias and poor prognosis. Conversely, the various definitions of cardiac remodelling stress on common molecular, biochemical, and mechanical pathways. Although the right ventricle and left ventricle show significant distinctions in embryology, form, and function, they have many similar findings when they adjust to damaging loading or when they fail. Having a number of key differentiations in their molecular response to failure this offer a future platform for right ventricle for a particular therapeutic intervention. It has been suggested by Friedberg and Redington in 2014 that "Focus on the molecular pathways specific to the failing right ventricle, and targeting the interactions between both ventricles may guide to successful treatments for the right ventricle and left ventricle failure". A shortly review is made with updated information for all factors that cause and affect cardiac remodelling process, especially in case of right heart.