Trypanocidal activity of oxoaporphine and pyrimidine-β-carboline alkaloids from the branches of annona foetida mart. (annonaceae)

Abstract

Phytochemical investigation of the branches of Annona foetida Mart. led to isolation from the CH 2Cl 2 extract of four alkaloids: Atherospermidine (1), described for the first time in this species, liriodenine (2), O-methylmoschatoline (3), and annomontine (4). Their chemical structures were established on the basis of spectroscopic data from IR, MS, NMR (1D and 2D), and comparison with the literature. Compounds 2-4 showed potent trypanocidal effect when evaluated against epimastigote and trypomastigote forms of Trypanosoma cruzi. © 2011 by the authors; licensee MDPI, Basel, Switzerland.