Children with relapsed or refractory nephroblastoma: Favorable long-term survival after high-dose chemotherapy and autologous stem cell transplantation

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Abstract

Background: High-dose chemotherapy (HDC) with autologous stem-cell rescue (ASCR) is a treatment option for pediatric patients with relapsed nephroblastoma. We present long term results of 9 patients treated between 1993 and 2013 at our center. Procedure: Reinduction therapy was carried out according to GPOH and SIOP recommendations. The conditioning regimen consisted of carboplatin (1200mg/m 2), etoposide (800mg/m 2; or 40mg/kg) and melphalan (180mg/m 2). Purging of the grafts with immunomagnetic CD34 positive selection was performed in 5 patients. Results: 8 of 9 Patients (90%) are alive without evidence of disease after a median follow-up of 8.5 years. Leukocyte engraftment occurred after a median of 10 days (range 8-12). Median numbers of 667/μl CD3+, 329/μl CD4+, 369/μl CD8+T cells and 949/μl B cells were reached after 180 days. No negative impact of CD34 selection was observed. No transplantation-related death occurred. Acute toxicity comprised mucositis III°-IV° in all and veno-occlusive disease in one patient. Long term effects probably related to treatment occurred in 3/7 evaluable patients and comprised hearing impairment, reduced renal phosphate reabsorption, mild creatinine elevation and hypothyroidism (n=1, each). Conclusion: Thus, in our experience HDC with ASCR is an effective treatment of recurrent or refractory nephroblastoma with acceptable side effects. However, a randomized trial proving its efficiency with a high level of evidence is needed.

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Illhardt, T., Ebinger, M., Schwarze, C. P., Feuchtinger, T., Furtwängler, R., Schlegel, P. G., … Lang, P. (2014). Children with relapsed or refractory nephroblastoma: Favorable long-term survival after high-dose chemotherapy and autologous stem cell transplantation. Klinische Padiatrie, 226(6–7), 351–356. https://doi.org/10.1055/s-0034-1390504

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