Investigation of self-assembly structure and properties of a novel designed lego-type peptide with double amphiphilic surfaces

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Abstract

A typically designed 'Peptide Lego' has two distinct surfaces: A hydrophilic side that contains the complete charge distribution and a hydrophobic side. In this article, we describe the fabrication of a unique lego-type peptide with the AEAEYAKAK sequence. The novel peptide with double amphiphilic surfaces is different from typical peptides due to special arrangement of the residues. The results of CD, FT-IR, AFM and DLS demonstrate that the peptide with the random coil characteristic was able to form stable nanostructures that were mediated by non-covalent interactions in an aqueous solution. The data further indicated that despite its different structure, the peptide was able to undergo self-assembly similar to a typical peptide. In addition, the use of hydrophobic pyrene as a model allowed the peptide to provide a new type of potential nanomaterial for drug delivery. These efforts collectively open up a new direction in the fabrication of nanomaterials that are more perfect and versatile.

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Wang, L., & Zhao, X. J. (2010). Investigation of self-assembly structure and properties of a novel designed lego-type peptide with double amphiphilic surfaces. Bulletin of the Korean Chemical Society, 31(12), 3740–3744. https://doi.org/10.5012/bkcs.2010.31.12.3740

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