Neutrophils are an emerging cellular source of IFN-γ, a key cytokine that mediates host defense to intracellular pathogens. Production of IFN-γ by neutrophils, in contrast to lymphoid cells, is TLR- and IL-12–independent and the events associated with IFN-γ production by neutrophils are not understood. In this study, we show that mouse neutrophils express IFN-γ during their lineage development in the bone marrow niche at the promyelocyte stage independently of microbes. IFN-γ accumulates in primary neutrophilic granules and is released upon induction of degranulation. The developmental mechanism of IFN-γ production in neutrophils arms the innate immune cells prior to infection and assures the potential for rapid release of IFN-γ upon neutrophil activation, the first step during responses to many microbial infections.
CITATION STYLE
Sturge, C. R., Burger, E., Raetz, M., Hooper, L. V., & Yarovinsky, F. (2015). Cutting Edge: Developmental Regulation of IFN-γ Production by Mouse Neutrophil Precursor Cells. The Journal of Immunology, 195(1), 36–40. https://doi.org/10.4049/jimmunol.1500366
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