A mathematical model of pHi regulation in central CO2 - Chemoreception

Abstract

In CO2 chemosensitive neurons, an increase in CO2 (hypercapnia) leads to a maintained reduction in intracellular pH (pH i) while in non-chemosensitive neurons pHi recovery is observed. The precise mechanisms for the differential regulation of pH i recovery between these cell populations remain to be identified; however, studies have begun to explore the role of Na+/H+ exchange (NHE). Here, we compare the results of two different formulations of a mathematical model to begin to explore pHi regulation in central CO2 chemoreception. © 2008 Springer Science+Business Media, LLC.