Systemic Lupus Erythematosus

Abstract

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that can affect almost every organ system. It is characterized by a heterogenous presentation, and disease manifestations often evolve over time. It is more common in women, specifically in women of childbearing age (female-to-male ratio 9:1). In the pediatric populations, the ratio is 2-6:1 and in the elderly 3-8:1, female-to-male. SLE can be seen in all ethnic groups. In the United States, SLE is more common in African-Americans, and African-Americans are more likely to have higher morbidity and mortality than Caucasians.