CLASSIFICATION AND MECHANISM OF BACTERIOCIN INDUCED CELL DEATH: A REVIEW

Abstract

Multidrug resistance and toxicity associated with antimicrobial agents among pathogenic bacteria leading to a surge in morbidity and mortality in humans need bold proclamation in the area of research and development of new biological agents. The maximum propitious possibility we can see in the area of bacteriocins. Bacteriocins are ribosomally synthesized peptides produced by gram-positive and gramnegative bacteria which evince wide and narrow antimicrobial activity spectrum. They can survive in a highly competitive microbial environment. Bacteriocins attack their targeted bacterial cells through different mechanisms. Understanding different mechanisms that induced cell death will enable researchers to develop methodologies to limit this life-threatening problem. Therefore, in this study, we provide the updated information on the number of bacteriocins produced, their potential producers and different mode of action against relevant pathogenic bacteria.