Tracer kinetic modelling

Abstract

This chapter provides an overview of the basic principles of quantification of cerebral PET studies using compartmental modelling. Both single- and two-tissue compartment models are presented with emphasis on volume of distribution and non-displaceable binding potential as outcome measures. Next, both full and simplified reference tissue models are introduced, obviating the need for arterial cannulation. Finally, a brief overview is given of various parametric methods enabling calculations at a voxel level.