Rabbit antithymocyte globulin causes Blastomyces and Histoplasma antigenemia

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Abstract

Rabbit antithymocyte globulin (rATG) is known to yield false-positive Histoplasma antigenemia. The fourth generation MiraVista Histoplasma antigen assay was modified to block this effect (MiraVista Diagnostics, Indianapolis, Indiana). We report a case of rATG-induced false-positive Blastomyces and Histoplasma antigenemia in a lung transplant recipient despite modifications of these antigen assays.

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Kaur, A., Eberlein, M., Klesney-Tait, J., Durkin, M. M., Wheat, L. J., & Gajurel, K. (2019). Rabbit antithymocyte globulin causes Blastomyces and Histoplasma antigenemia. Open Forum Infectious Diseases, 6(5). https://doi.org/10.1093/ofid/ofz165

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