Synthesis of dihydropyrano[4,3-b]pyranes via a multi-component reaction catalyzed by lipase

Abstract

A green method for the synthesis of dihydropyrano[4,3-b]pyranes via a three-component reaction catalyzed by lipase is reported firstly. Under the optimal conditions, high yields of dihydropyrano [4,3-b]pyranes (80.8-96.8%) could be obtained in this enzymatic reaction. This study not only expands the application of lipase in organic synthesis, but also provides an alternative efficient method for the synthesis of dihydropyrano[4,3-b]pyranes. (Image presented).