Use of the calcium agonist bay K 8644 for In vitro diagnosis of susceptibility to malignant hyperthermia

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Abstract

We have studied the effects of the calcium agonist BAY K 8644 on the in vitro halothane test in 10 malignant hyperthermia-susceptible (MHS), 12 MH "equivocal" to halothane (MHEh), 30 MH non-susceptible (MHN) and 10 control patients. BAY K 8644 potentiated the halothane-induced contracture in muscle strips from both MHS and MHEh patients. The drug produced a more obvious difference in contracture responses between the MHEh group compared with the MHN and control groups. © 1990 Copyright: 1990 British Journal of Anaesthesia.

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Adnet, P. J., Krivosic-horber, R. M., Haudecoeur, G., Adamantidis, M. M., Reyford, G. H., Imbenotte, M., & Cordonnier, C. (1990). Use of the calcium agonist bay K 8644 for In vitro diagnosis of susceptibility to malignant hyperthermia. British Journal of Anaesthesia, 65(6), 791–795. https://doi.org/10.1093/bja/65.6.791

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