A synthetic chloride channel restores chloride conductance in human cystic fibrosis epithelial cells

61Citations
Citations of this article
50Readers
Mendeley users who have this article in their library.

Abstract

Mutations in the gene-encoding cystic fibrosis transmembrane conductance regulator (CFTR) cause defective transepithelial transport of chloride (Cl-) ions and fluid, thereby becoming responsible for the onset of cystic fibrosis (CF). One strategy to reduce the pathophysiology associated with CF is to increase Cl- transport through alternative pathways. In this paper, we demonstrate that a small synthetic molecule which forms Cl- channels to mediate Cl- transport across lipid bilayer membranes is capable of restoring Cl- permeability in human CF epithelial cells; as a result, it has the potential to become a lead compound for the treatment of human diseases associated with Cl- channel dysfunction. © 2012 Shen et al.

Cite

CITATION STYLE

APA

Shen, B., Li, X., Wang, F., Yao, X., & Yang, D. (2012). A synthetic chloride channel restores chloride conductance in human cystic fibrosis epithelial cells. PLoS ONE, 7(4). https://doi.org/10.1371/journal.pone.0034694

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free