In situ fiber-optic dissolution assisted by a mathematical separation model of dynamic three-wavelength K-ratio spectrophotometry

Abstract

The aim of this study was to monitor the drug release of ibuprofen sustained-release capsules in real time in situ. A mathematical separation model of dynamic three-wavelength K-ratio spectrophotometry was established to eliminate the interference of gelatin capsule shells when drug release was monitored by a fiber-optic drug dissolution in situ test system. A control experiment with high performance liquid chromatography was performed simultaneously. Within 7 h, real-time drug release profiles were obtained. The average drug release rates were 19.79%, 37.34%, 63.13%, and 88.41% by the fiber-optic drug dissolution in situ test system at the respective time points of 1 h, 2 h, 4 h, and 7 h. There were no significant differences between the in situ and control methods. Drug release of ibuprofen sustained-release capsules can be monitored by the fiber-optic drug dissolution in situ test system assisted by the mathematical separation model of dynamic three-wavelength K-ratio spectrophotometry. Information about the entire dissolution process can be produced by the real-time release profile.