48REDUCED BASELINE INFLAMMATION MAY BE ASSOCIATED WITH GREATER ACUTE DECLINES IN MUSCLE MASS FOLLOWING ELECTIVE COLORECTAL SURGERY

Abstract

Background: Acute sarcopenia is an emerging condition affecting older adults following hospitalisation. It is declined as incident sarcopenia within six months, normally preceded by a stressor event. Chronic sarcopenia has been associated with increased chronic inflammation, but the relationship of acute and chronic inflammatory response with acute sarcopenia is yet to be determined. Methods: Enzyme-Linked Immunosorbent Assays were performed to measure preoperative serum concentration levels of high sensitivity C-Reactive protein (hsCRP), cortisol, dehydroepiandrosterone sulfate (DHEA-S), and vitamin D for seven participants recruited to a pilot study measuring acute sarcopenia in older surgical patients. Results: A positive association was demonstrated between baseline DHEA-S and change in gait speed from preoperative assessment to one week postoperatively (τb = 0.87, p = 0.02). A positive association was also demonstrated between baseline hsCRP and change in Bilateral Anterior Thigh Thickness (BATT). Conclusion: The results of this pilot study suggest that there may be an association baseline inflammation and development of acute sarcopenia. Further research should focus on evaluating mechanisms including clinical and biochemical correlates to enable targeting of interventions.