Haplotype inference

Abstract

Haplotypes, as they specify linkage patterns between individual nucleotide variants, confer critical information for understanding the genetics of human diseases. However, haplotype information is not directly obtainable from high-throughput genotyping platforms. In this chapter, we introduce two representative methods to reconstruct haplotypes from unphased genotype data, one method is for unrelated individuals and the other is for families. © 2012 Springer Science+Business Media, LLC.