Cortical modularity is a fundamental microanatomic feature of the brain with direct implications for the cognitive function of cortical microcircuits. Neural activity recorded simultaneously with multi-electrode arrays (MEAs) from supra- and infra-granular layers along adjacent cortical minicolumns in PFC was shown to extract microanatomic codes relevant for successful behavioral performance. In addition, it is shown that pharmacologic agents disrupt the micro-anatomic processing and cognitive performance, but that recovery from cognitive impairment is produced by application of a cognitive prosthesis, via nonlinear multi-input multi-output (MIMO) model stimulation of microanatomic outputs with successful MIMO codes. The functional basis of this approach provides the potential for applying cognitive prostheses to a broad range of neurological and psychiatric dysfunctions involving cortical processes.
CITATION STYLE
Deadwyler, S. A., Opris, I., Santos, L. M., Hampson, R. E., Gerhardt, G. A., Song, D., … Berger, T. W. (2015). Extraction of cortical modularity patterns for neural prosthetics. In Recent Advances On The Modular Organization Of The Cortex (pp. 367–384). Springer Netherlands. https://doi.org/10.1007/978-94-017-9900-3_19
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