Factors Associated with the Decline of C-Peptide in a Cohort of Young Children Diagnosed with Type 1 Diabetes

12Citations
Citations of this article
19Readers
Mendeley users who have this article in their library.

Abstract

Context: Understanding factors involved in the rate of C-peptide decline is needed to tailor therapies for type 1 diabetes (T1D). Objective: Evaluate factors associated with rate of C-peptide decline after a T1D diagnosis in young children. Design: Observational study. Setting: Academic centers. Participants: A total of 57 participants from the Environmental Determinants of Diabetes in the Young (TEDDY) study who were enrolled at 3 months of age and followed until T1D, and 56 age-matched children diagnosed with T1D in the community. Intervention: A mixed meal tolerance test was used to measure the area under the curve (AUC) C-peptide at 1, 3, 6, 12, and 24 months postdiagnosis. Outcome: Factors associated with rate of C-peptide decline during the first 2 years postdiagnosis were evaluated using mixed effects models, adjusting for age at diagnosis and baseline C-peptide. Results: Adjusted slopes of AUC C-peptide decline did not differ between TEDDY subjects and community controls (P = 0.21), although the former had higher C-peptide baseline levels. In univariate analyses combining both groups (n = 113), younger age, higher weight and body mass index z-scores, female sex, an increased number increased number of islet autoantibodies, and IA-2A or ZnT8A positivity at baseline were associated with a higher rate of C-peptide loss. Younger age, female sex, and higher weight z-score remained significant in multivariate analysis (all P < 0.02). At 3 months after diagnosis, higher HbA1c became an additional independent factor associated with a higher rate of C-peptide decline (P < 0.01). Conclusion: Younger age at diagnosis, female sex, higher weight z-score, and HbA1c were associated with a higher rate of C-peptide decline after T1D diagnosis in young children.

Cite

CITATION STYLE

APA

Steck, A. K., Liu, X., Krischer, J. P., Haller, M. J., Veijola, R., Lundgren, M., … Elding Larsson, H. (2021). Factors Associated with the Decline of C-Peptide in a Cohort of Young Children Diagnosed with Type 1 Diabetes. Journal of Clinical Endocrinology and Metabolism, 106(3), E1380–E1388. https://doi.org/10.1210/clinem/dgaa715

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free