GenPop – An Online Tool to Analyze Human Population Genetic Data

Abstract

GenPop is a web based online cross platform tool developed to help Geneticist and Epidemiologist to deal with association studies in analyzing human population genetic data. The tool features include descriptive analysis such as Hardy-Weinberg equilibrium test, chi-square p-value and analysis of single nucleotide polymorphisms (SNPs) with multiple inheritance models such as dominant, recessive, allelic, genotype, odd's ratio and relative risk at 95% confidence interval and analysis of multiple SNPs including haplotype frequencies and linkage disequilibrium for a pair of biallelic markers. This is a user-driven human population genetic data analysis tool that is easily scalable and acceptable with multiple implementations of different algorithms. GenPop has been developed using PHP, JavaScript and with PHPExcel library to analyse the genetic data for case control studies. Background: Genetic epidemiology deals with the study the role of genetic factors involved in determining health and diseases in families and as well in populations which seeks to derive statistical and