Synthesis of BiOCl nanoplatelets as the dual interfaces for the detection of glutathione linked disease biomarkers and biocompatibility assessment in vitro against HCT cell lines model

Abstract

Nanotechnology provides a great opportunity to design multifunctional materials that can be applied for diverse platforms. As a case study, we prepared bismuth oxychloride nanoplatelets (BiOCl–NPLs) and used as bifunctional interfaces to bind biomarkers, selectively, as well as their biocompatibility potential was assessed. The structures were prepared by a facile and efficiently designed hydrothermal method and possess layered nanoplatelets morphology. The phase composition was investigated by XRD which is in accordance with the tetragonal structure of BiOCl. EDS confirmed the surface elemental composition, whereas, FTIR analysis validated the molecular structure of the prepared structures. BiOCl–NPLs modified interfaces were found remarkable to bind glutathione, an important disease biomarker. The material showed a significant sensing response to bind glutathione, which highlights its diagnostic applications. And the biocompatibility is investigated towards the human colorectal carcinoma cell line (HCT 116) using MTT assay in vitro. Our results showed that BiOCl–NPLs are non-cytotoxic, an important feature for biomedical use. The present study leads a pathway to design dual-functional materials for diagnostic and clinical applications.