Classification of the human papilloma viruses

Abstract

In this study we present a whole-genome phylogenetic classification of the human papilloma viruse (HPV) family. We found that the high risk of carcinogenicity taxa are clustered together. The most likely insertion and deletion (indel) scenarios of HPV nucleotides were computed. We also searched for relationships between the number of indels which occurred during the evolution of the HPV family and the degree of carcinogenicity of considered taxa. Linear and polynomial redundancy analyses (RDA) were carried out to relate the HPV carcinogenicity with the number of insertions, deletions and conservations. © Springer-Verlag Berlin Heidelberg 2011.