Applications of Hydrophobins in Medical Biotechnolog

Abstract

Class I and class II Hydrophobins are small, low molecular weight cysteine-rich protein produced by filamentous fungi, of approximately 100 amino acids, whose size ranges between 5-20 kDa. Research over the last 10 years gave an improved insight into the applications of hydrophobins in the medical and pharmaceutical fields. The study of hydrophobins, self-assembly between hydrophobic and hydrophilic interfaces led to a better understanding of physical properties and their applications. Different coatings which use anti-fouling agents like hydrophobins are used for fabricating medical devices to provide bacteriocidal and antiplatelet activity for instance by fusion of SC3-NO-releasing medical-grade polymer; formation of antibacterial surfaces. Hydrophobins have been used for making Nano suspensions of water-insoluble drugs to increase their efficiency/effectiveness and for better oral administration.In addition to it, Hydrophobins are used for immobilization of molecules and cells, Detection of antigen-antibody interaction. This review highlights the study of a significant wide range of applications by various methods, also showcasing the need for developing new product strategies to improve the low yields for their broader use. Hydrophobins being a promising protein gives widespread opportunities for their application in medical and therapeutics.