Antibiotic exposure and its relationship to postantibiotic effect and bactericidal activity: Constant versus exponentially decreasing tobramycin concentrations against Pseudomonas aeruginosa

Abstract

In vitro postantibiotic effects (PAES) exhibited by a standard strain of Pseudomonas aeruginosa following exposure to tobramycin at constant concentrations were compared to those at exponentially decreasing concentrations. Exposure to a constant concentration showed more extensive bacterial killing and resulted in longer PAEs at comparable areas under the concentration-time curves above the MIC. This phenomenon suggests a significant contribution of pharmacokinetics to antimicrobial pharmacodynamics.