A trans-Regulatory code for the forebrain expression of Six3.2 in the Medaka fish

Abstract

Background: The transcription factor Six3 is key element of forebrain specification, but its upstream regulators are unknown. Results: A systematic search in medaka fish identifies and functionally characterizes novel Six3 regulators. Conclusion: The spatio-temporal regulation of Six3 depends on a few trans-acting factors. Significance: This study provides new information on how forebrain neuronal diversity is originated.