Lipid Signals in the Resolution of Inflammation

Abstract

Acute inflammation is an indispensable host defence mechanism, and its proper resolution is important in keeping tissue homeostasis. The resolution of inflammation involves active cellular and molecular programs that enable inflamed tissues to return to homeostasis. The mechanisms by which acute inflammation is resolved are of interest, and research in recent years has uncovered novel endoge-nous mechanisms that involve eosinophils, macrophages, and their lipid signals in controlling acute inflammation and resolution.