Yin Yang 1 (YY1) and P53 Gene Expression Analysis in Cervical Cancer and Its Relationship with Cancer Staging

Abstract

Cervical cancer is the global 2nd most prevalent cancer with ± 266 000 related deaths. Yin Yang 1 (YY1) is a ubiquitous and multifunctional zinc-finger transcription factor in controlling cell cycle. Similarly, p53 suppressestumors by selectively inhibiting carcinogenesis. The interventional study aims to evaluate YY1 and p53 gene expressions in cervical cancer, serving for further treatment and intervention. The study measured YY1 and p53 mRNA gene expressions by quantitative real-time PCR through blood sample, which was analyzed by t-test and correlation. Moreover, demographics and medical history were acquired through interviews and medical records. 20 samples are selected by random sampling from July to September 2016. YY1 and cervical cancer stage has negative correlation (r: -0.5) due to its inhibition of cell growth until a certain phase of cancer cell development. While, positive correlation between p53 and cancer stage (r: 0.47) was found because of p53 gene dysregulation. YY1 and p53 correlation are negative (r: -0.9) due to their conflicting functions. The study describes the correlation between YY1 and p53 gene expressions in cervical cancer stages. It was found that the downregulated YY1 expression in cervical cancer as the stage progress is directly opposed to the p53 gene trend. The higher YY1 and lower p53 gene expressions dictate the likelihood of surgery. Therefore, YY1 and p53 can be utilized as a cervical cancer progression indicator and surgery indicator.