Comparing quick sequential organ failure assessment scores to end-tidal carbon dioxide as mortality predictors in prehospital patients with suspected sepsis

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Abstract

Introduction: Early identification of sepsis significantly improves outcomes, suggesting a role for prehospital screening. An end-tidal carbon dioxide (ETCO2) value ≤ 25 mmHg predicts mortality and severe sepsis when used as part of a prehospital screening tool. Recently, the Quick Sequential Organ Failure Assessment (qSOFA) score was also derived as a tool for predicting poor outcomes in potentially septic patients. Methods: We conducted a retrospective cohort study among patients transported by emergency medical services to compare the use of ETCO2 ≤ 25 mmHg with qSOFA score of ≥ 2 as a predictor of mortality or diagnosis of severe sepsis in prehospital patients with suspected sepsis. Results: By comparison of receiver operator characteristic curves, ETCO2 had a higher discriminatory power to predict mortality, sepsis, and severe sepsis than qSOFA. Conclusion: Both non-invasive measures were easily obtainable by prehospital personnel, with ETCO2 performing slightly better as an outcome predictor.

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L. Hunter, C., Silvestri, S., Ralls, G., Stone, A., Walker, A., Mangalat, N., & Papa, L. (2018). Comparing quick sequential organ failure assessment scores to end-tidal carbon dioxide as mortality predictors in prehospital patients with suspected sepsis. Western Journal of Emergency Medicine, 19(3), 446–451. https://doi.org/10.5811/westjem.2018.1.35607

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