Detection of ribavirin in environmental and biological samples via optical chemical sensor

Abstract

Aim: This study was conducted to determine the Ribavirin in Environmental and Biological Samples via Optical Chemical Sensor. Methodology: In this paper, a new magnetic metal-organic framework Fe3O4@Fe-ASB was synthesized with nano-Fe3O4 as metal center and a new Schiff base, which was synthesized from quinoline-2-formaldehyde and β-mercaptoethylamine, as ligand, This Fe3O4@Fe-ASB was characterized by FITR, SEM and XRD. Its enzyme-like activity was characterized by the chromogenic substrate (H2O2 and TMB) and verified based on the Michaelis-Menten equation. Results: The results showed that the synthesis of Fe3O4@Fe-ASB was successful and it exhibited excellent enzyme-like activity. The Fe3O4@Fe-ASB was successfully used for the detection of ribavirin in water samples as catalytic material. It showed good stability, accuracy and precision. This testing method features a graph, which plots concentration (cribavirin) on the x-axis and absorption A on the y-axis to create a linear equation. It shows a good linear relation ranging from 1×10-4 mol l-1 to 1×10-6 mol l-1, with a limit detection of 2×10-7 mol 1-1. The mean recovery rates for spike recovery experiments varied from 92.0 % to 109 %. Interpretation: A new Schiff base was synthesized from quinoline-2-formaldehyde and β-mercaptoethylamine. Then, a new magnetic metal-organic framework Fe3O4@Fe-ASB was synthesized by it with nano-Fe3O4 as the metal center. The Fe3O4@Fe-ASB was successfully used for the detection of ribavirin in water samples as catalytic material. It showed good stability, accuracy and precision.