Abstract
Cembrane-type diterpenoids are a large and structurally varied group of natural products isolated from both terrestrial and marine organisms. From a biomedical perspective, cytotoxicity is the most remarkable property of this class of diterpenoids, respresented by sarcophytol A. The present paper reviews all the cytotoxic metabolites of cembrane diterpenes, reported up to 2013. The natural products discussed in this review can be divided into several different structural families featuring a variety of ring sizes and oxidation patterns. The currently hypothetical biosynthesis and total syntheses of some representative cembrane diterpenoids will be presented as well.
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Yang, B., Liu, J., Wang, J., Liao, S., & Liu, Y. (2015). Cytotoxic cembrane diterpenoids. In Handbook of Anticancer Drugs from Marine Origin (pp. 649–672). Springer International Publishing. https://doi.org/10.1007/978-3-319-07145-9_30
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