Comparison of serum osteocalcin with total and bone specific alkaline phosphatase and urinary hydroxyproline: Creatinine ratio in patients with paget’s disease of bone

Abstract

Osteocalcin or bone Gla protein (BGP) is secreted by osteoblasts, and its serum concentration is elevated in a number of conditions with high bone turnover. A comparison of serum osteocalcin with total (TALP) and bone specific alkaline phosphatase (BALP) and urinary hydroxyproline/creatinine (OHP/Cr ratio) was performed in 13 patients with active Paget's disease of bone. BGP did not correlate significantly with either BALP or TALP, but did show a significant correlation with OHP/Cr ratio (r = 0·76; P<0·01). BGP does not appear to be as sensitive a marker as BALP or TALP in Paget's disease. © 1994, Association for Clinical Biochemistry. All rights reserved.