MiR-30c-1* promotes natural killer cell cytotoxicity against human hepatoma cells by targeting the transcription factor HMBOX1

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Abstract

Natural killer (NK) cells play a critical role in antitumor immunity, and the activation of NK cells is regulated by a series of NK cell receptors. Here, we show that crosslinking CD226, an important NK cell receptor, with the anti-CD226 mAb LeoA1 on NKL cells, regulated the expression of several microRNA and transmembrane tumor necrosis factor-α. Among them, miR-30c-1* was noticed because overexpression of miR-30c-1 * triggered upregulation of transmembrane tumor necrosis factor-α expression and enhanced NK cell cytotoxicity against hepatoma cell lines SMMC-7721 and HepG2. Furthermore, we proved that the inhibitory transcription factor HMBOX1, which depressed the activation of NK cells, was the direct target gene of miR-30c-1 *. In conclusion, our results revealed a novel regulatory mechanism: miR-30c-1 * promoted NK cell cytotoxicity against hepatoma cells by targeting HMBOX1. © 2012 Japanese Cancer Association.

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APA

Gong, J., Liu, R., Zhuang, R., Zhang, Y., Fang, L., Xu, Z., … Chen, L. (2012). MiR-30c-1* promotes natural killer cell cytotoxicity against human hepatoma cells by targeting the transcription factor HMBOX1. Cancer Science, 103(4), 645–652. https://doi.org/10.1111/j.1349-7006.2012.02207.x

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