Encapsulation of natural polyphenols with antioxidant properties in polyelectrolyte capsules and nanoparticles

Abstract

The chapter summarizes approaches to encase natural polyphenols with previously demonstrated anti-cancer potential, curcumin, (-)-epigallocatechin gallate, tannic acid, theaflavin, thearubigin, curcumin, etc. in polyelectrolyte microcapsules and nano/microparticles in order to modulate their biological activity, bioavailability and stability as an alternative to usage of free compounds. Taking into account the matrix-encapsulate interaction, the emphasis is made to the techniques based on reversible complex electrostatic interaction and hydrogen bonding of polyphenols with polymeric matrixes, stability and properties of the obtained microstructures as delivery vehicles, characteristics of polyphenol loading, and factors affecting their release from the nanocapsules. The controversies in manifesting biological and antioxidant activity by polyphenols encased in the aforementioned structures are discussed.