Genetics and neurobiology of Alzheimer's disease and frontotemporal dementias

Abstract

Alzheimer's Disease (AD), Lewy body variant of AD, and the frontotemporal dementias are the three most common causes of adult onset dementia. This chapter will examine the genetic basis of AD and Lewy body variant, familial British dementia and familial encephalopathy with neuronal dementia with neuroserpin deposits, tau mutations in FTDP-17, and the practical implications of genetic testing. © 2006 Humana Press Inc.