The relationship of lipid profi le with severity of disease and mortality in patients with COVID-19

Abstract

OBJECTIVES: Serum total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol may be associated with a poor prognosis in COVID-19 patients. BACKGROUND: We think it may be essential to understand the role of lipids in the pathophysiology of COVID-19. METHODS: One hundred eighty-nine patients admitted to the emergency department between 20th January and 20th February 2021 and later decided to be hospitalized to an inpatient clinic or intensive care unit were included in the study. The patients were determined to be hospitalized to the inpatient clinic or intensive care unit according to the Turkish Ministry of Health COVID-19 guidelines. A demographic information form was established for each patient. RESULTS: The primary fi ndings we have obtained were as follows: (1) CRP, PCT, D-Dimer levels were found to be high, while Albumin, TC, HDL-c, and LDL-c levels were found to be low in critical type patients; (2) CRP, PCT, and D-Dimer levels were higher in the patients who were intubated compared to those who were not intubated. Albumin and HDL levels were low; (3) DH was found to have a signifi cantly negative relationship with TC and HDL-c, and (4) Sensitivity of LDL-c in predicting mortality was found as 69 % and specifi city as 70 %. It was observed that patients with low LDL-c levels had higher mortality rates. CONCLUSION: We think that hypocholesterolaemia may be an indicator of the impending danger. Our study examined COVID-19 in terms of lipid metabolism and offers a different perspective on the disease (Tab. 4, Ref. 23). Text in PDF www.elis.sk