Absence of TLR4 Asp299Gly and Thr399Ile polymorphisms in Chinese Han population with type 2 diabetes

Abstract

Objective: This study was performed to detect the association between the Asp299Gly and Thr399Ile polymorphisms of the TLR4 gene and type 2 diabetes in the Chinese Han population. Methods: The study included 856 unrelated individuals with type 2 diabetes and 672 healthy controls. The polymorphisms of the TLR4 gene were examined through denaturing high-performance liquid chromatography. Results: Neither the Asp299Gly nor the Thr399Ile polymorphism was detected in any of the diabetic and healthy subjects. Conclusions: Our finding indicates the Asp299Gly and Thr399Ile polymorphisms of the TLR4 gene are very rare in the Chinese Han population.