Modulatory role of VEGF in angiogenesis for cell survival

Abstract

Vascular endothelial growth factor (VEGF) is established to play a crucial role in angiogenesis, cell survival, and thus appear to be important in many pathophysiological processes. VEGF and anti VEGF therapy have been used in treatment of cancer, diabetic retinopathy, cardiovascular disorders, psoriasis, wound healing, age-related macular degeneration, and so on. This review elaborates role of VEGF as cell survival factor in various diseases and several therapeutic strategies involving VEGFs and their receptors. The development of side effects and resistance to therapy involving VEGF needs to be considered while designing new molecules along with molecular modeling techniques.