Visceral fat accumulation, insulin resistance, and elevated depressive symptoms in middle-aged Japanese men

8Citations
Citations of this article
45Readers
Mendeley users who have this article in their library.

Abstract

Objective: To investigate visceral fat accumulation and markers of insulin resistance in relation to elevated depressive symptoms (EDS). Methods: Participants were 4,333 male employees (mean age, 49.3 years) who underwent abdominal computed tomography scanning, measured fasting insulin, and did not self-report diabetes and mental disorders under treatment and history of cancer, myocardial infarction, and stroke. Multivariable logistic regression was used to assess the association of EDS with abdominal fat deposition and markers of insulin resistance. Results: Visceral fat area (VFA) and fasting insulin were significantly, positively associated with EDS. Multivariable-adjusted odds ratios (95% confidence interval) of high VFA for the lowest through highest quartile of depression score were 1 (reference), 1.18 (0.97-1.42), 1.25 (1.02-1.54), 1.23 (1.01-1.51), respectively, and corresponding figures for high fasting insulin were 1 (reference), 0.98 (0.80-1.19), 1.12 (0.91-1.38), and 1.29 (1.06-1.57), respectively. Subcutaneous fat area was not associated with EDS. Conclusions: Results suggest that EDS is related to visceral, but not subcutaneous, fat accumulation and insulin resistance in middle-aged Japanese men.

Cite

CITATION STYLE

APA

Yamamoto, S., Matsushita, Y., Nakagawa, T., Honda, T., Hayashi, T., Noda, M., & Mizoue, T. (2016). Visceral fat accumulation, insulin resistance, and elevated depressive symptoms in middle-aged Japanese men. PLoS ONE, 11(2). https://doi.org/10.1371/journal.pone.0149436

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free